so here is how I have TweetDeck set up in its own Space (bottom left) on my macbook pro (click the images to go to Flickr and see full sizes).
all tweets from everyone I’m following on the far left (rarely look at), Pals next (about 50 people I really follow), Watch (tech and news followings) and replies.
Continued in Part 2 (since TweetDeck scrolls right)…
Asheville group (from a Summize search for Asheville so I can see if anyone is tweeting about my hometown), PartnerCentric (from Summize search on term partnercentric, which is where I work), Wofford group (from Summize search on my alma mater), Replies and then Direct Messages.
looks crazy, but works well for me!